Appetite and body weight : integrative systems and the development of anti-obesity drugs/
Edited by Tim C. Kirkham and Steven J. Cooper.
- x, 371 pages : illustrations
Includes index.
Includes references.
Introduction and overview -- Cortical systems involved in appetite and food consumption -- Nucleus accumbens shell as a model of integrative subcortical forebrain systems regulating food intake -- Hypothalamic neuropeptides and feeding regulation -- Brainstem-hypothalamic neuropeptides and the regulation of feeding -- Gut-brain axis in the control of eating -- Integration of peripheral adiposity signals and psychological controls of appetite -- Brain reward systems for food incentives and hedonics in normal appetite and eating disorders -- Pharmacology of food, taste and learned flavor preferences -- Role of palatability in control of human appetite: implications for understanding and treating obesity -- Learned influences on appetite, food choice, and intake: evidence in human beings -- Gene environment interactions and the origin of the modern obesity epidemic: a novel nonadaptive drift scenario -- Preclinical developments in antiobesity drugs -- Clinical investigations of antiobesity drugs.
Provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation.